Drug codes appear here only when a CMS NDC–HCPCS crosswalk lists at least one of this drug’s NDC packages. CodeRx never assigns a code from the name or ingredient.
J8501JJ-code: Drugs administered other than oral method; chemotherapy drugsActiveDerived calculation
Aprepitant, oral, 5 mg
Derived: 24 of 25 NDC package(s) for this drug appear in the CMS NDC–HCPCS crosswalk for J8501. CMS quarters Q1 2021 – Q4 2026
J-codes are permanent national codes for drugs and biologicals — most often clinician-administered (buy-and-bill) products paid under Medicare Part B — plus certain immunosuppressive, inhalation (via DME), and oral anticancer/antiemetic drugs. Units are reported in multiples of the dosage in the code descriptor.
03
NDC packages
Package NDCs from the FDA directory, normalized to the 11-digit 5-4-2 format used on claims.
Billable units per package for each NDC are listed in the NDC packages table above (CMS “BILLUNITSPKG”).
05
Reimbursement
Medicare Part B payment limits for the codes above, then how the home infusion per diem S-codes are paid. Commercial payer rates, AWP, and WAC are not included.
Medicare coverage is set nationally (NCDs) and by each Medicare Administrative Contractor (LCDs and Billing & Coding articles). These links open the official documents.
Diagnosis codes (ICD-10-CM) in Medicare billing articles
ICD-10-CM codes that Medicare contractors' Billing and Coding articles list as supporting medical necessity for this drug's HCPCS codes — covered diagnoses, not how often each is used. Washington (Noridian JF) articles come first; other contractors' articles are linked below.
No current Medicare Billing and Coding article lists J8501.
09
Code history
Quarterly changes to the HCPCS codes linked to this drug.
J8501
History for J8501
Quarterly file
Change
CMS action code
Details
Q1 2023
In earliest ingested file
N — No maintenance
Added date Jan 1, 2005
10
Data sources
11
Limitations and disclaimers
FDA NDC Directory data is submitted by labelers; FDA notes that inclusion does not mean the information was verified or that a product is approved, covered, or reimbursable.
HCPCS links are derived from CMS NDC–HCPCS crosswalks, which support ASP-based Part B payment and are not a complete list of billable NDCs.
Product class (brand, generic, biosimilar) is derived from the FDA marketing category and Purple Book license type, not from a commercial compendium.
Payment limits are Medicare Part B national limits; they do not reflect payer contracts, OPPS rates, 340B pricing, or acquisition cost.
Home infusion per diem S-codes are matched by therapy category from the FDA pharmacologic class and route, not from a CMS crosswalk. Payers choose which per diem codes they accept, and the right code can depend on the dosing schedule, infusion method, or daily volume.
Disclaimer. This application provides informational coding and reimbursement reference data. It does not constitute legal, clinical, coding, or billing advice. Codes, payment amounts, payer rules, and coverage policies can change. Verify all information with current CMS publications, the applicable payer, and your organization’s compliance policies before submitting a claim. CodeRx is not affiliated with or endorsed by CMS, FDA, Medicare, or any payer.
Official CMSCMSHCPCS Level II Quarterly Update (Alpha-Numeric HCPCS File)Q4 2026·Effective Oct 1, 2026 – Dec 31, 2026·Published Updated 09/23/2026·Imported Oct 15, 2026 05:52 UTCSource file (opens CMS website)
Derived calculationDrug-to-code links are aggregated from NDC-level CMS crosswalk rows.
Home infusion per diem (S-codes)
When a home infusion pharmacy dispenses this drug, the drug is billed with the code above and each day of pharmacy services, supplies, and equipment with a per diem S-code. CMS publishes no drug-to-per-diem crosswalk, so CodeRx picks the therapy category from the FDA pharmacologic class and route. S-codes are not payable by Medicare; confirm the code against the payer contract.
Home infusion per diems apply to infused or injected therapy; FDA lists this drug’s route(s) as oral.
Verification neededCodeRx links to coverage documents instead of copying them: CMS distributes their code lists under AMA, ADA, and AHA license terms that limit reuse. Medicare Advantage, Medicaid, and commercial plans set their own coverage and prior-authorization rules.