Methotrexate

Injection, methotrexate sodium, 50 mg

Derived: 15 of 40 NDC package(s) for this drug appear in the CMS NDC–HCPCS crosswalk for J9260. CMS quarters Q1 2021 – Q4 2026

J-codes are permanent national codes for drugs and biologicals — most often clinician-administered (buy-and-bill) products paid under Medicare Part B — plus certain immunosuppressive, inhalation (via DME), and oral anticancer/antiemetic drugs. Units are reported in multiples of the dosage in the code descriptor.

Home infusion per diem (S-codes)

When a home infusion pharmacy dispenses this drug, the drug is billed with the code above and each day of pharmacy services, supplies, and equipment with a per diem S-code. CMS publishes no drug-to-per-diem crosswalk, so CodeRx picks the therapy category from the FDA pharmacologic class and route. S-codes are not payable by Medicare; confirm the code against the payer contract.

• Chemotherapy

  Derived calculationVerification needed

  Matched on: Folate Analog Metabolic Inhibitor

  • S9329General chemotherapy per diemCMS: Home infusion therapy, chemotherapy infusion
  • S9330Continuous infusion (24 hours or more)CMS: Home infusion therapy, continuous (twenty-four hours or more) chemotherapy infusion
  • S9331Intermittent infusion (less than 24 hours)CMS: Home infusion therapy, intermittent (less than twenty-four hours) chemotherapy infusion

  Payers use either the general per diem or the detailed codes, not both — follow the contract.

Source

• Official CMSCMSMedicare Part B Drug Payment Limit File (ASP pricing file)Q4 2026·Effective Oct 1, 2026 – Dec 31, 2026·Published 09/17/2026 - Final file·Imported Oct 23, 2026 03:44 UTCSource file (opens CMS website)
• Official CMSCMSHCPCS Level II Quarterly Update (Alpha-Numeric HCPCS File)Q4 2026·Effective Oct 1, 2026 – Dec 31, 2026·Published Updated 09/23/2026·Imported Oct 15, 2026 05:52 UTCSource file (opens CMS website)

Home infusion per diem (S-codes)

Medicare

Not payable by Medicare — CMS coverage code I (all 3 codes)

Part B pricing indicator

00 — Not separately priced by Part B (all 3 codes)

National payment amount

None. No per diem code here is in the CMS Part B payment limit file for Q4 2026; CMS sets no national per diem rate.

Washington Apple Health (Medicaid)

Not on HCA’s Home Infusion Therapy/Parenteral Nutrition Program fee schedule (effective Jul 1, 2026), so these per diems are not separately paid. Home infusion is paid with the supply, pump, and nutrition codes in that schedule instead (below).

Billing unit

1 unit = 1 day on service (the CMS descriptor ends “per diem”)

Who sets the rate

Each commercial plan’s contract or state Medicaid fee schedule. Some payers reduce a second per diem billed for the same day.

Billed separately

The drug, with its own HCPCS code and units, and nursing visits — the CMS descriptor says “drugs and nursing visits coded separately”.

Verification neededCodeRx links to coverage documents instead of copying them: CMS distributes their code lists under AMA, ADA, and AHA license terms that limit reuse. Medicare Advantage, Medicaid, and commercial plans set their own coverage and prior-authorization rules.

• Official CMSCMSMedicare Coverage Database — Current Article Data (Billing and Coding articles)2026-11-05·Effective as of publication·Published Last-Modified Thu, 05 Nov 2026 07:00:11 GMT·Imported Nov 7, 2026 05:33 UTCSource file (opens CMS website)

Every import with its checksum is listed on the data sources page.